Biotech volatility continues through 2023 and overall we are sideways.

– Bong Koh

Several acquisitions or major deals in the areas of inflammation/immunology and metabolic disease will emerge.

– Alex Rosen

Biotech will go “back to basics”. The market will value real products addressing unmet needs over hype.

– Cami Samuels

The new generation of weight loss drugs spawns the next Cerebral. Read the outcomes of our 2022 predictions and learn what our 10 predictions for 2023 are here.

– Bob Kocher & Bryan Roberts

Dive In With

David Ebersman

Co-Founder & CEO, Lyra Health

Advice to founders in health tech?

One challenge in health tech is that the different functional leaders across clinical, product, sales, etc., are usually not fluent in each others’ languages. It took Lyra several years to get a team together that could communicate effectively and the company didn’t start working until that happened.

What are you most proud of regarding Lyra and its journey?

We published a peer-reviewed paper in 2022 showing that 89% of clients treated by Lyra had a clinically meaningful improvement in their depression or anxiety symptoms.

Most surprising learning about mental health since founding Lyra?

I have been surprised by how quickly societal attitudes about mental health have been changing, specifically the decline in stigma that has historically deterred people from seeking mental health care. We have been gratified to see consistently higher than expected utilization of our services, in particular by younger people.

Best holiday present that you gave this year?

I did not send any emails or Slacks to my teammates for the week between Christmas and New Year's.

Thinking Long Term is the Greatest Gift

Farzad Mostashari  |  Founder and CEO of Aledade
with Bob Kocher & Bryan Roberts

Diversifying the Cap Table

Heather Fernandez  |  Co-Founder and CEO of Solv with Bob Kocher & Bryan Roberts

The Balancing Act of Drug Discovery

Larry Hamann  |  Co-Founder, President, and CEO of Interdict Bio with Mariana Mihalusova

Course Correcting for Long-Term Success

Jigar Raythatha  |  Former CEO of Constellation Pharmaceuticals with Andrew Gottesdiener

Dive In With

Ken Song

President & CEO, RayzeBio

Favorite thing about biotech? Most frustrating thing?

Favorite thing is that novel science and innovation seem limitless and better therapies are coming to market. Most frustrating thing is that companies and our industry continue to let failed concepts/hypotheses linger rather than shutting them down. Too much of a “hope springs eternal” mindset.

Top advice for entrepreneurs?

Only pursue working on something that you love doing. You never need a vacation from work because it becomes intertwined with your life and you fully embrace it.

An unexpected positive that has come out of this year?

Controlled clinical data showing early signs of improving Alzheimer’s disease (lecanemab). Once a small amount of progress has been made, it usually opens up the door to newer therapies that can have a more meaningful impact.

Recommend literally anything.

Be grateful in all circumstances. There is good in everything. You just have to look at it the right way.

Devoted Health has grown to include nearly 124K members and shared their origin story.

Read More:  linkedin.com   |   fortune.com

Aledade became a public benefit corporation and their CEO Farzad Mostashari was recognized for his influence shaping policy.

Read More:  aledade.com   |   modernhealthcare.com

Element launched a new throughput-based option for its AVITI System, their first DNA sequencing product.

Read More:  elementbiosciences.com   |   fiercebiotech.com

Biohaven Pharmaceuticals, a biopharmaceutical company with innovative drug candidates targeting neurological diseases, was acquired by Pfizer for $11.6B.

Read More:  fiercebiotech.com

Included Health joined forces with SCAN Health Plan to create the first-ever Medicare Advantage plan for older LGBTQ+ adults.

Read More:  includedhealth.com

Lyra Health expanded globally and ramped up focus on workplace and childhood mental health.

Read More:  lyrahealth.com   |   fiercehealthcare.com   |   fiercehealthcare.com

Akouos, a hearing loss gene therapy, was snapped up by Eli Lilly.

Read More:  fiercebiotech.com

This tale of self-discovery revolves around a shepherd who learns the true importance of who he is, how to better himself, and how to focus on the important aspects of life while following his dream – an Egyptian treasure hunt.

– Nimish Shah

In depth look at one of the most exciting seasons for Arsenal – the ups and downs of Premier League players, challenges and triumphs of a first time coach, and how the organization is run. A fascinating roller coaster.

– Racquel Bracken

According to his Spotify Wrapped 2022, Bob is in the top 2% of Swifties. He recommends this album's bonus track, “Would've, Could've, Should've”, while doing the 30-minute Peloton ride with Ally Love for the full experience.

– Bob Kocher